Dr Anne Puel

Anne PUEL

Date of birth: 20th of June 1967

Nationality: French

Professional address:        Laboratory of Human Genetics of Infectious Diseases (HGID), INSERM U1163, University Paris Descartes, Imagine Institute, 24 boulevard du Montparnasse, 75015 Paris, France.

Tel: +33 1 2 75 43 19; Fax: +33 1 42 75 42 24, E-mail: anne.puel@inserm.fr

Highest Degrees                                                                                                                                                                  

2013:      Habilitation to direct Researches (HDR; University Paris Descartes, Paris V, France)

1996:      PhD in Science, specialty Immunology (University Paris VI, Paris, France)

Education                                                                                                                                                                                                                                       

Since 2014:            Associate Professor (Directeur de Recherche DR2, INSERM), Adjunct Senior Research Associate at the Rockefeller University (NYC, USA)

HGID Laboratory, INSERM U1163, Imagine Institute, Paris and Rockefeller University, NYC, USA

Group leader: «Human genetic predisposition to fungal diseases»

2006-2014:             Assistant professor (Chargée de Recherche CR1, INSERM)

HGID Laboratory, INSERM U980, Necker Faculty of Medicine, Paris Descartes University, Paris.

Group leader: «Human genetic predisposition to fungal diseases» and co-leader of the group: «Human genetic predisposition to bacterial diseases »

2002- 2006:            Postdoctoral researcher

GHMI Laboratory, INSERM U980, Necker Faculty of Medicine, Paris Descartes University, Paris. «Human genetic predisposition to bacterial diseases »

2000- 2002:            Postdoctoral researcher

Laboratory of Cellular Immunology, INSERM U543, La Pitié Salpétrière Hospital, Paris. “Cellular and molecular mechanisms regulating quantitative antibody production in Biozzi mice”

1997- 2000:            Post-doctoral fellow

Laboratory of Molecular Immunology, the NIH, Bethesda, Maryland, USA. « Identification of the genetic basis for human TB+NK+ SCID: IL-7RA deficiency »

1992- 1996:             PhD in Immunology

Laboratory of Cellular and Clinical Immunology, INSERM U255, Curie Institute, Paris. “Cellular and molecular mechanisms regulating quantitative antibody production in Biozzi mice”

1991- 1992:             Master 2 in Immunology

Institut Pasteur and University Pierre et Marie Curie, Paris VI, Paris

1990- 1991:             Master 1 in Biochemistry, Option Pharmacology

USTL, Montpellier, France

Distinctions                                                                                                                                                                                                                                    

2010: Translational research contract INSERM-AP-HP

2011: INSERM Outstanding Science Award

2014: Doctoral Research and Research Award

2014: Translational research contract INSERM-AP-HP

License                                                                                                                                                                                                                                             

2009: License contract (N° 08445A10) between INSERM Transfer and SPALTUDAQ Corporation (Theraclone Sciences), human anti-IL-6 autoantibodies purification

Research grants as principal investigator                                                                                                                            

– French National Research Agency (ANR) GENCMCD. “Genetic dissection of chronic mucocutaneous candidiasis in humans” (2012, for three years)

– Translational Research Program Grant Award. “Novel primary immunodeficiencies underlying invasive fungal diseases”. Jeffrey Modell Foundation (2014, for two years)

– ANR HGDIFD. “Human genetic determinism of invasive fungal diseases” (2015, for four years)

– Cross-lab project. “Inborn errors of the keratinocyte‐leukocyte cross‐talk in humans” (2018, for three years)

– ANR-FNS LTh-MSMD-CMCD. “Lymphocyte T helper (Th) cell differentiation in patients with inborn errors of immunity to Mycobacterium and/or Candida species” (2019, for 4 years)

Expertise                                                                                                                                                                                 

– Member of the scientific advisory board “Congrès des Jeunes Chercheurs en Biologie Prix René Descartes” (since 2007), FEBS Advanced Lecture Course on Human Fungal Pathogens (since 2015)

– Expert for grant evaluation (Association Vaincre la Mucoviscidose, UPMC, ANR, Wellcome Trust, and ERC)

– Referee for diverse journals (Nature Communications, Cell Host & Microbe, Journal of Experimental Medicine, New England Journal of Medicine, Blood, , American Journal of Human Genetics, Journal of Human Genetics, EMBO Molecular Medicine, Molecular Cell, Journal of Allergy and Clinical Immunology, Journal of Immunology, Journal of Immunological Methods, Journal of Clinical Immunology, PLOS Pathogens, PLOS ONE, Frontiers in Immunology, Clinical Immunology, Virulence, British Journal of Dermatology, Clinical Infectious Diseases, Trends in Molecular Medicine, BMJ Case Reports,  etc)

– Associate Editor (Journal of Clinical Immunology, Frontiers in Immunology since 2017 and 2016, respectively)

Chair of the ESID Working Party Genetics (2018-2022)

– Workshop organizer at the XIVth meeting of ESID, Istanbul (6-9 October 2010)

Ten Main Relevant Publications (out of 160 in PubMed, (H index 57))                                                              

  1. Béziat V, Li J, …//…, Puel A**, Casanova JL*. 2018. A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity. Sci Immunol. Jun 15; 3(24).
  2. Israel L, Wang Y, …//…, Casanova JL*, Puel A**. 2017. Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity. Cell. 168(5):789-800.
  3. Lévy R, Okada S, ..//.. Casanova JL*, Puel A**. 2016. Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency. Proc Natl Acad Sci U S A 113: E8277-E8285
  4. Toubiana J, Okada S, ..//.. Casanova JL*, Puel A**. 2016. Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype. Blood 127: 3154-64
  5. Okada S*, Markle JG*,..//.. Puel A, Sallusto F*, Bustamante J*, Tangye SG*, Casanova JL. 2015. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations. Science 349: 606-13
  6. Ling Y, Cypowyj S, .//. , Casanova JL*, Puel A**. 2015. Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. J Exp Med. 212:619-31
  7. Lanternier F, Mahdaviani SA, ..//.., Casanova JL, Puel A*. 2015. Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species-induced meningoencephalitis, colitis, or both. J Allergy Clin Immunol 135:1558-68.e2
  8. Lanternier F, Pathan S,..//., Casanova JL*, Picard C*, Grimbacher B*, Puel A**. 2013. Deep dermatophytosis and inherited CARD9 deficiency. N Engl J Med 369: 1704-14
  9. Puel A**, Cypowyj S*,..//.., Picard C, Casanova JL. 2011. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science 332: 65-8
  10. Liu L*, Okada S*,..//.., Puel A**, Casanova JL*. 2011. Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. J Exp Med 208: 1635-48

Bachelor, master, or PhD students and postdoc supervision                                                                                            

Supervision of over 25 M1, M2 and MD students, 10 PhD students, 15 post-docs and 4 technicians

Teaching activities (~25hrs/year)                                                                                                                                        

Involved in several Master and PhD courses (since 2011)