Prof Stuart Tangye

Stuart Tangye is Director of Immunity & Inflammatory Diseases Research Theme at the Garvan Institute of Medical Research (Sydney, Australia), and Professor in the Faculty Medicine, UNSW Sydney. He completed his PhD at the University of Technology Sydney in 1995 and then undertook postdoctoral training at the DNAX Research Institute for Molecular and Cellular Biology (Palo Alto California, USA). It was during this time that his passion for human immunology, cell biology and immune deficiencies was ignited. He returned to Australia in 2000 as a University of Sydney Research Fellow to work with Dr Phil Hodgkin at the Centenary Institute of Cancer Medicine and Cell Biology. He established his own independent research lab in 2002, was recruited to the Garvan Institute in 2006, and appointed Research Director in 2015.

His research interests focus on the biology of human lymphocytes in health and disease, and elucidating mechanisms whereby defects in signalling, activation and function underlie the development and clinical features of immunodeficiencies. This is achieved by studying lymphocyte biology in patients with diseases resulting from inborn errors of immunity in key regulators of immune responses. His lab has made significant contributions to elucidating how these mutations result in the clinical features associated with human primary immunodeficiencies, including understanding the requirements for generating memory B cells, Tfh cells and Th17 cells, and defects in immune responses to EBV infection.

He has published ~185 peer-reviewed articles, has been funded by the National Health and Medical Research Council of Australia, Cancer Council NSW, NIH, Jeffrey Modell Foundation, XLP Research Trust, Association for International Cancer Research, and the Job Research Foundation. He also holds major positions on the editorial boards of J Exp Med, J Immunol, J Clin Immunol and Front Immunol, and is currently the chair of the IUIS Expert Committee of Inborn Errors of Immunity. His contributions to research have been recognized by being awarded the Gottschalk Medal from the Australian Academy of Sciences (‘outstanding research in the medical sciences by scientists under 40 years’; 2011), the Faculty of Science UTS Alumni Award for Excellence (2013), a Fulbright Scholarship from the USA:Australian Fulbright Commission (2015), and the Presidential Award from the Clinical Immunology Society (USA, 2019).

When he is not at work, he enjoys surfing, cycling, swimming and being a Dad to his three beautiful children, and partner to his amazing wife Gill!

Dr Stuart Tangye is currently an NHMRC-funded Principal Research Fellow in the Immunology department at the Garvan Institute of Medical Research, and an Associate Professor in the Faculty Medicine, University of NSW. He completed his PhD on B-cell leukemia under the supervision of Prof Bob Raison at the University of Technology Sydney in 1995 and then undertook postdoctoral training at the DNAX Research Institute for Molecular and Cellular Biology (Palo Alto California, USA; 19996-1999) in the laboratories of Drs. Jan de Vries, Joe Phillips and Lewis Lanier. It was during this time that his passion for human immunology, cell biology and immune deficiencies was ignited. He returned to Australia in 2000 as a University of Sydney Research Fellow to work with Dr Phil Hodgkin at the Centenary Institute of Cancer Medicine and Cell Biology (University of Sydney). He established his own independent research lab in 2002, and was recruited to the Garvan Institute in 2006.

His research interests focus on the biology of human lymphocytes in health and disease, and elucidating mechanisms whereby defects in signalling, activation and function underlie the development and clinical features of several immunodeficiencies. This is achieved by studying lymphocyte development, signalling, differentiation and effector function in patients with diseases resulting from monogenic loss-of-function mutations in key regulators of immune responses, such as XLP, X-SCID, AD and AR-HIES, as well as in corresponding animal models of these human conditions. In the past few years, his lab has made significant contributions to elucidating how these mutations can result in some of the clinical features that are associated with these immunodeficiencies.

He is funded by fellowships and project and program grants awarded by the NHMRC, Cancer Council NSW, XLP Research Trust and Association for International Cancer Research. Since 1995, he has published >90 peer-reviewed articles and invited reviews. In 2011, he received the Gottschalk Medal from the Australian Academy of Sciences, which recognises “outstanding research in the medical sciences by scientists no more than 40 years of age”. When he is not at work, he enjoys surfing, cycling, swimming and most of all being a Dad to his three beautiful children!